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Effects of Klika Faloak (Sterculia Populifolia) Extract Cream Toward MMP-1 Expression of Albino Mice Against Ultraviolet B Radiation

Effects of Klika Faloak (Sterculia Populifolia) Extract Cream Toward MMP-1 Expression of Albino Mice Against Ultraviolet B Radiation
by : Nur Khairi, Suryani As’ad, Khairuddin Djawad, and Gemini Alam

abstract : Klika Faloak (Sterculia Populifolia) extract contains flavonoid and polyphenol compounds which are the most potential components in reducing ROS (Radical Oxidative Superoxide) to prevent free radical caused by UV-B radiation. This study aimed to prove that Klika Faloak extract cream could reduce the expression of matrix metalloproteinase-1 (MMP-1) in albino mice exposed to UV-B radiation. This study was a laboratory experimental study using randomized pre and post-test design. Albino mice were divided into 3 groups; group 1 was treated with 0.1 mg/cm2 on 3 cm2 of radiation area with 5% Klika Faloak extract cream for four weeks and exposed to UVB radiation, group 2 was treated with 0.1 mg/cm2 on 3 cm2 of radiation area with base cream/ placebo for four weeks and exposed to UVB radiation, and group 3 was controlled group which not given anything and not exposed to UVB radiation. Prior to the treatment, MMP-1 expression was examined through blood serum and then the treatment group was exposed to UV-B radiation at a dose of 500 mJ/cm2 for 4 weeks. After that skin biopsy was performed to examine MMP-1 expression. Data were analyzed using one way ANOVA to determine significant difference among three groups then followed by a post hoc test using the LSD (Least Significance Difference) to determine the smallest significant level <0.05. The result showed average decreasing of MMP-1 expression in group 1 compared to group 2 and group 3. It could be concluded that Klika Faloak extract cream could reduce MMP-1 expression.

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